Epigallocatechin Gallate Preferentially Inhibits O 6-Methylguanine DNA-Methyltransferase Expression in Glioblastoma Cells Rather than in Nontumor Glial Cells


Scientists compared the effects of EGCG on glioblastoma cell lines and found that EGCG enhances the effects of TMZ on cancer cells but not healthy cells.

And that EGCG works by inhibiting the creation of the protein MGMT, which when not inhibited in brain cancer, usually confers resistance to chemotherapy and therefore a shorter life expectancy.

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