Off-Label and Natural Brain Cancer Treatment Options

    TreatmentClincial Trial DosagePossible SyngergiesChemoprotective?Mechanism(s) of ActionOpen Trials?Clinical StudiesJournal ArticlesAdditional Information
    Boswellia Serrata4200mg daily in a study testing a reduction in brain swellingTemodarPossibly (demonstrated in cell based experiments)By initiating apoptosis (cell-suicide) in cancer cellsNone currently available12
    CurcuminUp to 1500mg daily has been shown to to be well tolerated non-oncology clincial studiesRadiation, TemodarThrough various pathwaysNone currently available

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    DietKetogenic - Daily & Long TermRadiation, Temodar, Perillyl AlcoholBy depriving cancer cells they resources they need to grow and creating ketones, which are cytotoxic to cancer cellsYes

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    EGCG (a compound found in Green Tea)4 - 6 cups dailyTemodarThrough various pathwaysNone currently available

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    Matcha Green Tea has the highest EGCG content
    FastingVarious types have been shown to be effectiveRadiation, TemodarYesCauses cellular stress which cancer cells can not adopt toNone currently available

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    Glucans (a mushroom extract)6 grams daily were used in one clincial trial that showed benefitMonoclonal AntibodiesBy stimlating the immune system and increasing the number of White Blood CellsNone currently available

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    There is a clinical study showing prolonged survival to liver cancer patients using Immpower
    High Dose Vitamin CMultiple times per week over multiple times up to 100gRadiation, TemodarYesThrough increasing Reactive Oxygen Species, which ultimately leads to cell deathNone currently available

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    Hyperbaric OxygenVarious number of sessions have been shown to have benefitRadiation, ChemotherapyThrough various pathwaysYes12
    The treatments can be covered by insurance if there is evidence of radiation necrosis
    Mebendazole500mg daily is currently under study in a trial at Johns HopkinsTemodarBy preventing cells from manufactoring the microtubules they need to divideYes12
    At present, Mebendazole is only available from a compounding pharmacy
    Melatonin20mg nightly has been shown to have benefit in multiple studiesTemodarYesThrough increasing Reactive Oxygen Species, which utlimately leads to cell deathNone currently available12
    MetforminUp to 850mg twice daily has been used in trials with little-to-no side effectsRadiation, TemodarThrough various pathwaysYes, 311
    Mistletoe TherapyVarying doses at different intervalsRadiation, TemodarYesBy activating various cells of the immune systemNone currently available11
    Though administered at home it requires the guidance of a Medical Provider, such as one found here: https://oncanp.org/
    Perillyl AlcoholUp to 4 times dailyTemodar, Ketogenic DietThrough various pathwaysYes, 12Ingredients for formulation
    QuercetinUp to 5 grams daily has been well tolerated in a non-oncology studyTemodarBy initiating apoptosis (cell-suicide) in cancer cellsNone currently available

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    Resveratrol500mg daily has been shown to to be well tolerated non-oncology clincial studiesTemodarYesThrough various pathwaysNone currently available

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    ZincUp to 75mg daily has been used in clinical trialsTemodarThrough p53 which is a tumor suppressor proteinYes, 1

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    Zinc Bisglycinate is the form of Zinc with the highest level of absorption
    BerberineUp to 300mg twice daily is currently under study in a clinical trialRadiation, TemodarThrough various pathways