Off-Label and Natural Brain Cancer Treatment Options

TreatmentClincial Trial DosageShown Synergies?Chemoprotective?Mechanism(s) of ActionNotesOpen TrialsClinical StudiesJournal Articles
Boswellia Serrata4200mg daily in a study testing a reduction in brain swellingTemodarPossibly (demonstrated in cell based experiments)By initiating apoptosis (cell-suicide) in cancer cellsNone currently available12
CurcuminUp to 1500mg daily has been shown to to be well tolerated non-oncology clincial studiesRadiation, TemodarThrough various pathwaysNone currently available

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3
DietKetogenic - Daily & Long TermRadiation, Temodar, Perillyl AlcoholBy depriving cancer cells they resources they need to grow and creating ketones, which are cytotoxic to cancer cellsYes

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5
EGCG (a compound found in Green Tea)4 - 6 cups dailyTemodarThrough various pathwaysMatcha Green Tea has the highest EGCG contentNone currently available

0

2
FastingVarious types have been shown to be effectiveRadiation, TemodarYesCauses cellular stress which cancer cells can not adopt toNone currently available

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2
Glucans (a mushroom extract)6 grams daily were used in one clincial trial that showed benefitMonoclonal AntibodiesBy stimlating the immune system and increasing the number of White Blood CellsThere is a clinical study showing prolonged survival to liver cancer patients using ImmpowerNone currently available

0

2
High Dose Vitamin CMultiple times per week over multiple times up to 100gRadiation, TemodarYesThrough increasing Reactive Oxygen Species, which ultimately leads to cell deathNone currently available

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2
Hyperbaric OxygenVarious number of sessions have been shown to have benefitRadiation, ChemotherapyThrough various pathwaysThe treatments can be covered by insurance if there is evidence of radiation necrosisYes12
Mebendazole500mg daily is currently under study in a trial at Johns HopkinsTemodarBy preventing cells from manufactoring the microtubules they need to divideAt present, Mebendazole is only available from a compounding pharmacyYes12
Melatonin20mg nightly has been shown to have benefit in multiple studiesTemodarYesThrough increasing Reactive Oxygen Species, which utlimately leads to cell deathNone currently available12
MetforminUp to 850mg twice daily has been used in trials with little-to-no side effectsRadiation, TemodarThrough various pathwaysYes, 311
Mistletoe TherapyVarying doses at different intervalsRadiation, TemodarYesBy activating various cells of the immune systemThough administered at home it requires the guidance of a Medical Provider, such as one found here: https://oncanp.org/None currently available11
Perillyl AlcoholUp to 4 times dailyTemodar, Ketogenic DietThrough various pathwaysIngredients for formulationYes, 12
QuercetinUp to 5 grams daily has been well tolerated in a non-oncology studyTemodarBy initiating apoptosis (cell-suicide) in cancer cellsNone currently available

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2
Resveratrol500mg daily has been shown to to be well tolerated non-oncology clincial studiesTemodarYesThrough various pathwaysNone currently available

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2
ZincUp to 75mg daily has been used in clinical trialsTemodarThrough p53 which is a tumor suppressor proteinZinc Bisglycinate is the form of Zinc with the highest level of absorptionYes, 1

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1
BerberineUp to 300mg twice daily is currently under study in a clinical trialRadiation, TemodarThrough various pathways