Off-Label and Natural Brain Cancer Treatment Options
Treatment | Clincial Trial Dosage | Shown Synergies? | Chemoprotective? | Mechanism(s) of Action | Notes | Open Trials | Clinical Studies | Journal Articles |
---|---|---|---|---|---|---|---|---|
Boswellia Serrata | 4200mg daily in a study testing a reduction in brain swelling | Temodar | Possibly (demonstrated in cell based experiments) | By initiating apoptosis (cell-suicide) in cancer cells | None currently available | 1 | 2 | |
Curcumin | Up to 1500mg daily has been shown to to be well tolerated non-oncology clincial studies | Radiation, Temodar | Through various pathways | None currently available | 0 | 3 | ||
Diet | Ketogenic - Daily & Long Term | Radiation, Temodar, Perillyl Alcohol | By depriving cancer cells they resources they need to grow and creating ketones, which are cytotoxic to cancer cells | Yes | 0 | 5 | ||
EGCG (a compound found in Green Tea) | 4 - 6 cups daily | Temodar | Through various pathways | Matcha Green Tea has the highest EGCG content | None currently available | 0 | 2 | |
Fasting | Various types have been shown to be effective | Radiation, Temodar | Yes | Causes cellular stress which cancer cells can not adopt to | None currently available | 0 | 2 | |
Glucans (a mushroom extract) | 6 grams daily were used in one clincial trial that showed benefit | Monoclonal Antibodies | By stimlating the immune system and increasing the number of White Blood Cells | There is a clinical study showing prolonged survival to liver cancer patients using Immpower | None currently available | 0 | 2 | |
High Dose Vitamin C | Multiple times per week over multiple times up to 100g | Radiation, Temodar | Yes | Through increasing Reactive Oxygen Species, which ultimately leads to cell death | None currently available | 0 | 2 | |
Hyperbaric Oxygen | Various number of sessions have been shown to have benefit | Radiation, Chemotherapy | Through various pathways | The treatments can be covered by insurance if there is evidence of radiation necrosis | Yes | 1 | 2 | |
Mebendazole | 500mg daily is currently under study in a trial at Johns Hopkins | Temodar | By preventing cells from manufactoring the microtubules they need to divide | At present, Mebendazole is only available from a compounding pharmacy | Yes | 1 | 2 | |
Melatonin | 20mg nightly has been shown to have benefit in multiple studies | Temodar | Yes | Through increasing Reactive Oxygen Species, which utlimately leads to cell death | None currently available | 1 | 2 | |
Metformin | Up to 850mg twice daily has been used in trials with little-to-no side effects | Radiation, Temodar | Through various pathways | Yes, 3 | 1 | 1 | ||
Mistletoe Therapy | Varying doses at different intervals | Radiation, Temodar | Yes | By activating various cells of the immune system | Though administered at home it requires the guidance of a Medical Provider, such as one found here: https://oncanp.org/ | None currently available | 1 | 1 |
Perillyl Alcohol | Up to 4 times daily | Temodar, Ketogenic Diet | Through various pathways | Ingredients for formulation | Yes, 1 | 2 | ||
Quercetin | Up to 5 grams daily has been well tolerated in a non-oncology study | Temodar | By initiating apoptosis (cell-suicide) in cancer cells | None currently available | 0 | 2 | ||
Resveratrol | 500mg daily has been shown to to be well tolerated non-oncology clincial studies | Temodar | Yes | Through various pathways | None currently available | 0 | 2 | |
Zinc | Up to 75mg daily has been used in clinical trials | Temodar | Through p53 which is a tumor suppressor protein | Zinc Bisglycinate is the form of Zinc with the highest level of absorption | Yes, 1 | 0 | 1 | |
Berberine | Up to 300mg twice daily is currently under study in a clinical trial | Radiation, Temodar | Through various pathways |